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While all links worked when entries were posted to the database, different publishers
have different policies about retaining articles and providing access to archived material.
Thus some of the links, particularly older ones, may no longer be functional.
For links no longer working, you may be able to gain paid access to text via the publisher's site.
Boys exposed to phthalates during pregnancy are less likely to choose “boy typical” toys such as trucks, suggesting that phthalates can alter brain development and gender-specific behaviors.
This is the first study to suggest a link between prenatal phthalate exposure and male behavior. The results indicate that phthalates can interfere with testosterone during development leading to a less masculinized brain. 16 November 2009. More...
A recent study links higher blood lead levels with high blood pressure in pregnant women, suggesting that lead exposure may increase the risk of developing hypertension during pregnancy.
All of the women in the study had blood levels below the level considered 'acceptable' by most health agencies, providing additional support for the need to lower the threshold. 10 August 2009. More...
Scorpion venom can change the way rats grow and develop if they are exposed to the neurotoxins before birth.
Scorpion stings are a public health problem in Brazil. This is one of a few studies to date to examine if scorpion venom poses a unique threat to developing offspring. The study clearly shows that baby rats are developmentally altered in many ways if their moms are "stung" while pregnant. 15 July 2009. More...
Researchers report that women with higher DDE blood concentrations were 2.5 times more likely to have high thyroid-stimulating hormone (TSH).
Increased concentrations of the long-lived pesticide residue were also associated with reduced thyroxine (T4) levels. Potential effects of chemicals on thyroid function during pregnancy are of concern because thyroid hormones play a crucial role in fetal brain development. 14 July 2009. More...
A detailed analysis of all the available studies comparing work-related, parental pesticide exposure and childhood leukemia finds that the mother’s exposure during pregnancy can double her child’s risk of the disease. The father’s exposure before pregnancy does not.
The study emphasizes the significant contribution of prenatal exposure in developing childhood disease and shows a need for more in-depth studies of the effects of prenatal exposures to environmental factors. 17 June 2009. More...
A five-generation rat study provides the clearest evidence to date that exposure to low levels of environmental estrogens can increase the risk of abnormal cell growth in the male breast.
Abnormalities which could have the potential to become cancerous developed in the mammary gland tissue of male rats that were exposed to either the soy-based phytoestrogen genistein or ethinyl estradiol -- an estrogen used in birth control pills. 27 May 2009. More...
New animal research suggests that overweight children may be at unique risk for adverse health problems due to exposure to dioxin before they are born.
Overweight mice whose mothers were exposed to dioxin during pregnancy die earlier, tend to have higher blood sugar levels and develop breasts sooner during puberty than those not exposed in the womb. Lean mice under the same circumstances had few of these effects. 21 May 2009. More...
Researchers report a higher risk of genital anomalies in boys exposed before birth to polybrominated biphenyl flame retardants.
Although no longer used, the effects of exposure to PBBs are of concern due to their similarity to currently used flame retardants, their long half-life and their ability to cross the placenta. The children of mothers who had the highest exposures also had a greater risk for urinary tract or genital problems. 15 May 2009. More...
A genetic trigger in the cell, long studied for its role in responding to some of the most toxic compounds known, appears to have newly discovered important functions in directing development.
The findings show that a receptor long-known to be responsive to dioxins can trigger different genes in the presence of pollutants than it does when no pollutants are around. The results point toward mechanisms that could help explain dioxin's impacts on fetal development. 29 April 2009. More...
Lead released from a woman's bones during pregnancy can affect her developing baby's DNA in ways that can alter gene expression and possibly increase the child's lifelong susceptibility to disease.
This is the first study to show that lead can influence genetic programming in human cells, and hence, gene expression, throughout life. 21 April 2009. More...
A single, modest exposure to caffeine during early development in the womb can alter heart growth and cardiac function later in life, finds this mouse study.
The results suggest even small amounts of caffeine delivered at the wrong time during development may change the heart. Since approximately 60 percent of women say they have consumed coffee during the first month of pregnancy, understanding the consequences of prenatal caffeine exposure is important. 14 April 2009. More...
A PCB mix altered reproductive hormones and organ growth in two generations of female rats that were never directly exposed to the chemicals themselves.
The abnormalities worsened in the granddaughters when compared to the daughters. The worst effects were seen at the mid -- not the highest or lowest -- level tested. Levels were within the range of human exposure. 27 February 2009. More...
Researchers in Taiwan find that phthalates can pass from pregnant women to their unborn babies and affect reproductive development in their daughters.
The paper reports an association between two types of the ubiquitous chemicals and permanent changes to the newborns' genitals that point to hormonal interference. Overall, the results provide more evidence that human exposure to these endocrine-disrupting chemicals before birth can alter how reproductive systems form. 30 January 2009. More...
Breast gland development is delayed in mice that were exposed for only a short time through their mothers -- during late pregnancy or while nursing -- to a now widely used chemical found in nonstick cookware and food packaging.
The results show that even a brief exposure to PFOA during a critical time of development can lead to long-term effects on the developing mammary gland. 29 January 2009. More...
A soy protein, genistein, long known to affect fertility, can change how pregnancies start and progress in female mice treated with it as newborns.
The changes make it harder for fertilized eggs to implant and grow, possibly contributing to infertility. The effects were observed at levels comparable to those experienced by human infants feeding on soy formula. 26 January 2009. More...
Women with potential exposure to pesticides at work or at home took longer to get pregnant than women without pesticide connections.
The findings agree with past studies and add more evidence to this sometimes confusing mix of research outcomes. 15 January 2009. More...
Another phthalate commonly found in the urine of U.S. residents was added to the list of those that are possibly contributing to the subtle feminization of boys.
Scientists report that DiBP (diisobutyl phthalate), used in plastics, varnishes and adhesives and detected commonly in people, causes changes in development of the reproductive tract of male rats when exposed in the womb. 31 October 2008. More...
Thirty-six scientists conclude in a peer-reviewed commentary that the FDA's draft decision on bisphenol A uses unacceptable criteria for selecting data and depends heavily upon a key paper that is fatally flawed.
The NIH-funded research rejected by the FDA is likely to produce reliable and valid scientific data than the studies used by the agency in its draft. 30 October 2008. More...
Prenatal exposure to polychlorinated biphenyls (PCBs) may lower a child's intelligence at age nine by several points, a study from Oswego, New York, finds.
The pre-teen children whose mothers were highly exposed to PCBs during pregnancy scored lower in general and verbal IQ tests than those born to mothers who were mildly exposed. The findings support other human studies that suggest exposure to these persistent chemicals disrupts early childhood mental development. 27 October 2008. More...
Adult men may have lower testosterone levels if their mother drank large amounts of coffee during pregnancy.
This new study from Denmark finds that the adult sons whose mothers drank large amounts of coffee during pregnancy had testosterone levels almost 10% lower than those whose mothers drank none to three cups of coffee per day. 5 October 2008. More...
Research in Denmark indicates that pregnant women exposed to pesticides at work have an increased risk of sons with abnormal reproductive development.
Their sons are more likely to have undescended testicles, smaller testicles and shorter penises. 4 October 2008. More...
A new study from China indicates that reducing air pollution from coal-burning power plants may improve children's ability to learn.
Children living near a recently closed coal-burning power plant performed better in a neurological development test compared to children living in the area three years prior when the plant was still in operation. 25 September 2008. More...
Mice exposed to low levels of soy proteins before and shortly after birth were obese as adults and had reproductive changes that differed between the sexes.
The findings provide additional evidence that hormonally active compounds can act at low exposure levels and produce effects different from those caused by high exposures. 24 September 2008. More...
A fungicide that blocks androgen hormone actions causes prostate inflammation in adult male rats that were exposed to the chemical before birth.
This is the first study to directly link an environmental contaminant known to disrupt an androgen hormone with prostate inflammation and provides novel insight into human origins of the disease. 20 September 2008. More...
In the first prospective study exploring how fetal exposures may affect the risk of childhood obesity, scientists from Spain report that children born to mothers with higher levels of the pesticide hexachlorobenzene in cord blood were significantly more likely to be overweight and obese by the age of six.
These results add to growing evidence that fetal exposure to contaminants can interfere with hormonal mechanisms that control weight later in life, thereby contributing to the world-wide epidemic of metabolic disorder. 22 August 2008. More...
Pregnant women exposed to household pesticides may increase the risk of their children developing leukemia, according to a recent study conducted in France.
In the study, parents of leukemia patients were more likely to have used pesticides and insecticides either at home or at work. Exposure to these chemicals is a risk factor for blood cancers, particularly if children are exposed in the womb, the authors' conclude. 5 February 2008. More...
Thirty-eight of the world's leading scientific experts on bisphenol A have warned policymakers of potential adverse health effects of exposure to the widespread molecule used to make plastic and food can lining.
They conclude that average levels in people are above those that cause harm to animals in laboratory experiments. And they calculate that average serum levels in people can only be explained by assuming that exposures today are already above the level that EPA considers safe. 13 August 2007. More...
Exposure to bisphenol A during development changes gene behavior in mice, causing genetically identical animals to develop differently.
BPA exposure reduces DNA methylation, thereby increasing the expression of genes that would have been silenced. The results can be counteracting by supplementing the maternal diet during pregnancy and lactation with nutrients that increase methylation, such as genistein, a phytoestrogen found in soy. 30 July 2007. More...
Women who reported mixing and applying agricultural pesticides during early pregnancy have a two times higher risk of developing gestational diabetes during the pregnancy.
Consistent with other studies, the strong association between first trimester pesticide exposure and gestational diabetes mellitus suggests that pesticide exposures, including 2,4,5-T and atrazine, may affect glucose metabolism and insulin resistance. 6 July 2007. More...
Prenatal exposure to a mixture of anti-androgenic chemicals produces changes in the structure of and genes expressed in male reproductive organs.
Rats exposed to a mixture of vinclozolin, flutamide and procymidone had abnormal development of the prostate, seminal vesicles and epididymis. Exposure to low doses of each individual chemical did not cause these effects but exposure to a mixture of low doses did, indicating an additive effect. This research has important implications for similar conditions in humans, who are routinely exposed to mixtures of low doses of chemicals. Toxicological Sciences 1 July 2007. More...
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